According to a report recently organized by the American Physicist Organization Network, scientists at Yale University in the United States have discovered a key cellular mechanism that can help the brain control our daily food intake, body weight, and ability to work when we are working. Related papers are published in the Journal of Neuroscience. Neurons in the hypothalamus regulate basic functions such as body temperature and feeding and maintain the energy balance of the body. The axons they emit are distributed throughout the nervous system. There are two functionally opposite neurons, one is a melanin-concentrating hormone (MCH) neuron and the other is a thyroid-stimulating hormone-releasing hormone (TRH) neuron. Scientists and pharmaceutical companies have been tracking the role of MCH neurons in controlling food intake and energy levels. Previous studies have shown that MCH neurons are associated with high calorie intake and low energy output, allowing lab animals to eat more and sleep better. More but no energy. Yale University researchers have discovered yet another counter-effector neuron, which uses the thyrotropin-releasing hormone TRH as a neurotransmitter, reduces food intake, loses weight, and increases physical activity. According to their studies on mouse brains, the two systems act diametrically to help maintain the balance of basic animal functions. Although TRH is an excitatory neurotransmitter, they inhibit MCH cells by introducing more inhibitory synapses, but TRH has no effect on other neurons, even though these neurons are also involved in energy regulation. Anthony Bol, professor of neurosurgery at Yale University School of Medicine and senior author of the paper, said: "The interaction between these two neurons at the level of synapses provides clues for us to study how the brain controls the amount of food intake and sleep time. â€
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U.S. Research Finds Cellular Mechanisms That Control Body Weight and Energy