Mechanism of action of oligosaccharide feed additives instead of antibiotics

Oligosaccharide refers to a branched or linear structure oligomer formed by 2 to 10 monosaccharides linked by glycosidic bonds. The oligosaccharides used as feed additives mainly include fructooligosaccharides and trans galactooligosaccharides. Soy oligosaccharides, grape oligosaccharides, mannooligosaccharides, xylooligosaccharides and low-focus sugars, etc., which have good physical and chemical properties such as low heat, stability, safety, non-toxicity, no residue, etc., have the balance of intestinal flora and improve immunity. And other functions.

The mechanism of action of oligosaccharides:

(1) As a beneficial microbial growth factor in the intestinal tract of animals. Oligosaccharides are not easily utilized by the body in the stomach and small intestine of animals, but can be decomposed by beneficial microorganisms in the posterior segment of the intestine, and used as a carbon source for microbial utilization. As a specific nutrient matrix, it selectively promotes the proliferation of beneficial bacteria in the intestinal tract of animals. To inhibit the growth and reproduction of harmful bacteria. The beneficial bacteria in the intestine can synthesize some vitamins, amino acids and other nutrients for absorption and utilization by the body. The acetic acid or lactic acid produced by fermentation can lower the intestinal pH value, facilitate the absorption of iron and calcium minerals and vitamin D, and promote lactose. The absorption of the indigestible saccharide cellulose into short-chain fatty acids improves fat metabolism.

(2) Prevent colonization of pathogenic bacteria in the intestinal tract. Some oligosaccharides have a structure similar to that of the intestinal epithelial oligosaccharide structural receptor, and can compete with the lectin of the pathogen for competitive binding, so that the pathogenic bacteria cannot adhere to the intestinal wall and are excreted with the oligosaccharide, even by adsorption. Pathogens that have adhered to the intestinal wall can be "eluted".

(3) Acting as a cofactor for immune stimulation. Oligosaccharides can bind to certain foreign antigens, slow down the absorption of antigens, increase the titer of antigens, and thus improve the functions of cellular immunity and humoral immunity.

(4) Elimination of carcinogenic factors and inhibition of tumor cell proliferation. It can reduce the carcinogenic factors produced by certain bacteria in the intestines and has the ability to inhibit the production of toxins by harmful bacteria to ensure the health of animals.